Preheat oven to 350 degrees F (175 degrees C). Gather all ingredients.
Line a large-rimmed baking sheet with aluminum foil. Press ground chuck into a thin, even 11- x 9-inch rectangle on prepared baking sheet. Sprinkle evenly with salt, pepper, and garlic powder.
Bake in preheated oven until a thermometer inserted into thickest portion of beef registers 140°F to 145°F, about 10 minutes. Using 2 large spatulas, transfer beef to a cutting board lined with paper towels; discard foil.
Line same baking sheet with a new piece of foil; lightly coat with cooking spray. Using a serrated bread knife, cut rolls in half horizontally, keeping top halves and bottom halves intact. Place the bottom half of rolls cut-side up on prepared baking sheet.
Spread Big Mac Sauce evenly over bottom half of rolls.
Place beef patty over sauce, topping evenly with cheese slices, pickles, and onion.
Place top half of rolls over pickles and onions. Brush tops and sides of rolls with melted butter, and sprinkle evenly with sesame seeds.
Bake in preheated oven until top buns are golden brown and cheese is melted, about 10 minutes.
Carefully remove bun tops, sprinkle lettuce in an even layer, and replace bun tops.
Cut sliders into 12 portions; serve with additional Big Mac Sauce.
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