15+ High-Protein Mediterranean Diet Casserole Recipes

Estimated read time 6 min read



Serve one of these flavorful and satisfying casseroles for dinner tonight. Each dish offers at least 15 grams of protein per serving from ingredients like poultry, seafood and legumes to help you stay full for longer. Plus, this collection features other delicious foods like whole grains, fish, vegetables, legumes and unsaturated fats like olive oil that also align with the Mediterranean diet, one of the most sustainable and nourishing eating patterns around. Recipes like our Chicken Enchilada Skillet Casserole and Baked Eggs in Tomato Sauce with Kale are nutritious and tasty meal options any night of the week.

Chicken Florentine Casserole

Photographer: Jen Causey, Food Stylist: Jennifer Wendorf, Prop Stylist: Lindsey Lower


This creamy chicken Florentine casserole combines tender pieces of chicken, fresh spinach and a rich, creamy sauce, all baked to perfection with a golden, cheesy crust. Whether you’re looking to cozy up on a chilly evening or share a hearty, home-cooked dinner with family, this casserole delivers an experience that feels like a warm hug on a plate.

Anti-Inflammatory Lemony Salmon & Orzo Casserole

Stacy k. Allen, Props: Julia Bayless, Food Stylist: Ana Kelley

This lemony salmon and orzo casserole is a one-dish dinner that’s packed with omega-3 fatty acids—a polyunsaturated fat in salmon that can help tame inflammation and may even help lower blood pressure. Here, omega-3-rich salmon sits on top of an orzo mixture that bakes in the oven, instead of boiling on the stovetop, absorbing all the bright and lemony flavors while it cooks.

Baked Eggs in Tomato Sauce with Kale

Ali Redmond


You can make these three-ingredient tomato-simmered eggs with things you probably already have on hand in your freezer and pantry. To make these baked eggs more like eggs in purgatory, look for a spicy tomato sauce and don’t forget some whole-wheat bread for dipping.

Teriyaki Chicken Skillet Casserole with Broccoli

Photographer: Brie Goldman, Food Stylist: Lauren McAnelly, Prop Stylist: Gabriel Greco


Whip up this quick and easy teriyaki chicken casserole in just one skillet—it’s the perfect go-to recipe for hectic weeknights that’s sure to satisfy a crowd. It’s ideal for making use of any leftover chicken and rice you have on hand.

Chicken & Quinoa Casserole

Photographer: Jen Causey, Food Stylist: Torie Cox, Prop Stylist: Claire Spollen

This aromatic and flavorful dish feels like veggie pizza in casserole form with fresh basil, herb-spiked diced tomatoes and ooey-gooey melted cheese on top. If you can’t find fresh mozzarella ciliegine, buy a larger ball and tear it into pieces. Preheating your baking sheets helps encourage caramelization of the roasted veggies, which adds layers of flavor to this savory dinner.

Pesto Tuna Noodle Casserole

Photographer: Grant Webster, Food Stylist: Holly Dreesman, Prop Stylist: Lexi Juhl


A creamy pesto sauce with sweet shallots and wilted spinach gives a light and bright spin to classic tuna noodle casserole. Albacore tuna is an ideal choice, as it holds its texture well once mixed in, although any water-packed tuna will do the job. For the best results, we recommend using refrigerated pesto for its fresh flavor which enhances the overall dish.

Chicken Fajita Casserole

Photographer: Rachel Marek, Food stylist: Holly Dreesman

This chicken fajita casserole combines classic fajita veggies and chicken thighs with corn tortillas and spices in one skillet for an easy dinner. Chicken thighs are tender and flavorful, but chicken breast or leftover chicken will work well too. Serve this easy casserole topped with your favorite fixings, like sour cream, avocado, salsa and/or chopped tomato.

Chicken Piccata Casserole

Photographer: Morgan Hunt Glaze, Prop Stylist: Shell Royster, Food Stylist Jennifer Wendorf


This protein-packed chicken piccata casserole brings all the flavors of classic chicken piccata together in one dish. It’s the easiest piccata you’ll ever make—no dredging or sauce required! Cooking the lemon slices in butter mellows their bite and helps jump-start the lemony flavor of the dish while helping the butter get a little brown, bringing some nuttiness to the dish.

Lemon-Garlic Chicken Casserole

Photographer: Morgan Hunt Glaze, Prop Stylist: Shell Royster, Food Stylist Jennifer Wendorf


This chicken and rice casserole packs in the protein plus offers plenty of fiber from brown rice and broccoli for a well-rounded meal in one pot. Chicken thighs are meaty and tender, but feel free to swap them out for chicken breast if you prefer.

Skillet Tuna Noodle Casserole

Photography / Fred Hardy, Styling / Ruth Blackburn / Audrey Davis

Known as Tuna-Pea Wiggle to some, this family-friendly tuna noodle casserole tends to be made with canned soup and whole milk, which means high fat and sodium. We remedy this by making our own creamy mushroom sauce with nonfat milk thickened with a bit of flour. Look for whole-wheat egg noodles–they have more fiber than regular egg noodles (but this dish will work well and taste great with either).

Chicken, Quinoa & Sweet Potato Casserole

This protein-loaded chicken and sweet potato casserole dish is made with multicolored quinoa, a blend of white, red and black varieties, but any color will work.

Creamed Spinach & Chicken Casserole

Fred Hardy, Food Stylist: Ruth Blackburn, Prop Stylist: Shell Royster

Creamed spinach and chicken combine in this crowd-pleasing, comforting casserole. Crushed red pepper packs some heat, so add less or leave it out completely if you want a milder version. You can cook long-grain brown rice ahead of time or look for packaged microwaveable brown rice to use instead.

Salmon Noodle Casserole

Photographer: Brie Goldman, Food Stylist: Charlie Worthington

This salmon noodle casserole is filled with creamy pasta, chunks of salmon and plenty of vegetables for a well-rounded meal. Dijon mustard flavors the dish, complementing the salmon and asparagus.

Chicken Enchilada Skillet Casserole

Jacob Fox

This simplified take on cheesy chicken enchiladas only requires one pan for cooking and eliminates the need to stuff and roll corn tortillas. Charring the veggies in a cast-iron skillet adds depth of flavor. Don’t worry if you don’t have one, because you can use any oven-safe skillet instead.

Spanakopita-Inspired Chicken & White Bean Casserole

Photographer: Carson Downing, Food stylist: Annie Probst, Prop Stylist: Joseph Wanek

This is a fun take on spanakopita, with a creamy feta-and-spinach filling and a crispy phyllo topping. Chicken and white beans pack in the protein. Any white beans, such as cannellini, garbanzo or navy beans, work well here. To keep the phyllo dough from drying out as you build the casserole, keep the unused sheets under a clean, damp towel.

Cheesy Black Bean & Quinoa Skillet Casserole

Rachel Marek

This Southwestern-inspired one-skillet casserole is stuffed with quinoa and plenty of fresh vegetables. Sharp Cheddar cheese flavors the filling and adds a layer of ooey-gooey melted cheese on top.



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